static void Main(string[] args)
{
    string sFile = "ExcelOpenXmlMultipleImageInsert.xlsx";
    if (File.Exists(sFile))
    {
        File.Delete(sFile);
    }
    try
    {
        BuildWorkbook(sFile);
    }
    catch (Exception e)
    {
        Console.WriteLine(e.ToString());
    }
    Console.WriteLine("Program end");
}

protected static void BuildWorkbook(string filename)
{
    using (SpreadsheetDocument xl = SpreadsheetDocument.Create(filename, SpreadsheetDocumentType.Workbook))
    {
        WorkbookPart wbp = xl.AddWorkbookPart();
        WorksheetPart wsp = wbp.AddNewPart<WorksheetPart>();
        Workbook wb = new Workbook();
        FileVersion fv = new FileVersion();
        fv.ApplicationName = "Microsoft Office Excel";
        Worksheet ws = new Worksheet();
        SheetData sd = new SheetData();

        WorkbookStylesPart wbsp = wbp.AddNewPart<WorkbookStylesPart>();
        wbsp.Stylesheet = CreateStylesheet();
        wbsp.Stylesheet.Save();

        Row r = new Row();
        r.RowIndex = 15;
        Cell c;
        c = new Cell();
        c.DataType = CellValues.String;
        c.StyleIndex = 1;
        c.CellReference = "G15";
        c.CellValue = new CellValue("We have multiple images!");
        r.Append(c);
        sd.Append(r);

        ws.Append(sd);
        wsp.Worksheet = ws;

        // It happens the resolution for the 3 images are 72 dpi
        // Images are 240 by 180 pixels
        // Adjust as needed

        InsertImage(ws, 0, 0, "cloudstreaks.jpg");
        // 2286000 = 180 (pixels) * 914400 (magic number) / 72 (bitmap resolution)
        InsertImage(ws, 0, 2286000, "crystallisedpavilion.png");
        // 3048000 = 240 (pixels) * 914400 (magic number) / 72 (bitmap resolution)
        InsertImage(ws, 3048000, 0, "dozingcat.jpg");

        wsp.Worksheet.Save();
        Sheets sheets = new Sheets();
        Sheet sheet = new Sheet();
        sheet.Name = "Sheet1";
        sheet.SheetId = 1;
        sheet.Id = wbp.GetIdOfPart(wsp);
        sheets.Append(sheet);
        wb.Append(fv);
        wb.Append(sheets);

        xl.WorkbookPart.Workbook = wb;
        xl.WorkbookPart.Workbook.Save();
        xl.Close();
    }
}

protected static void InsertImage(Worksheet ws, long x, long y, long? width, long? height, string sImagePath)
{
    try
    {
        WorksheetPart wsp = ws.WorksheetPart;
        DrawingsPart dp;
        ImagePart imgp;
        WorksheetDrawing wsd;

        ImagePartType ipt;
        switch (sImagePath.Substring(sImagePath.LastIndexOf('.') + 1).ToLower())
        {
            case "png":
                ipt = ImagePartType.Png;
                break;
            case "jpg":
            case "jpeg":
                ipt = ImagePartType.Jpeg;
                break;
            case "gif":
                ipt = ImagePartType.Gif;
                break;
            default:
                return;
        }

        if (wsp.DrawingsPart == null)
        {
            //----- no drawing part exists, add a new one

            dp = wsp.AddNewPart<DrawingsPart>();
            imgp = dp.AddImagePart(ipt, wsp.GetIdOfPart(dp));
            wsd = new WorksheetDrawing();
        }
        else
        {
            //----- use existing drawing part

            dp = wsp.DrawingsPart;
            imgp = dp.AddImagePart(ipt);
            dp.CreateRelationshipToPart(imgp);
            wsd = dp.WorksheetDrawing;
        }

        using (FileStream fs = new FileStream(sImagePath, FileMode.Open))
        {
            imgp.FeedData(fs);
        }

        int imageNumber = dp.ImageParts.Count<ImagePart>();
        if (imageNumber == 1)
        {
            Drawing drawing = new Drawing();
            drawing.Id = dp.GetIdOfPart(imgp);
            ws.Append(drawing);
        }

        NonVisualDrawingProperties nvdp = new NonVisualDrawingProperties();
        nvdp.Id = new UInt32Value((uint)(1024 + imageNumber));
        nvdp.Name = "Picture " + imageNumber.ToString();
        nvdp.Description = "";
        DocumentFormat.OpenXml.Drawing.PictureLocks picLocks = new DocumentFormat.OpenXml.Drawing.PictureLocks();
        picLocks.NoChangeAspect = true;
        picLocks.NoChangeArrowheads = true;
        NonVisualPictureDrawingProperties nvpdp = new NonVisualPictureDrawingProperties();
        nvpdp.PictureLocks = picLocks;
        NonVisualPictureProperties nvpp = new NonVisualPictureProperties();
        nvpp.NonVisualDrawingProperties = nvdp;
        nvpp.NonVisualPictureDrawingProperties = nvpdp;

        DocumentFormat.OpenXml.Drawing.Stretch stretch = new DocumentFormat.OpenXml.Drawing.Stretch();
        stretch.FillRectangle = new DocumentFormat.OpenXml.Drawing.FillRectangle();

        BlipFill blipFill = new BlipFill();
        DocumentFormat.OpenXml.Drawing.Blip blip = new DocumentFormat.OpenXml.Drawing.Blip();
        blip.Embed = dp.GetIdOfPart(imgp);
        blip.CompressionState = DocumentFormat.OpenXml.Drawing.BlipCompressionValues.Print;
        blipFill.Blip = blip;
        blipFill.SourceRectangle = new DocumentFormat.OpenXml.Drawing.SourceRectangle();
        blipFill.Append(stretch);

        DocumentFormat.OpenXml.Drawing.Transform2D t2d = new DocumentFormat.OpenXml.Drawing.Transform2D();
        DocumentFormat.OpenXml.Drawing.Offset offset = new DocumentFormat.OpenXml.Drawing.Offset();
        offset.X = 0;
        offset.Y = 0;
        t2d.Offset = offset;
        Bitmap bm = new Bitmap(sImagePath);

        DocumentFormat.OpenXml.Drawing.Extents extents = new DocumentFormat.OpenXml.Drawing.Extents();

        if (width == null)
            extents.Cx = (long)bm.Width * (long)((float)914400 / bm.HorizontalResolution);
        else
            extents.Cx = width;

        if (height == null)
            extents.Cy = (long)bm.Height * (long)((float)914400 / bm.VerticalResolution);
        else
            extents.Cy = height;

        bm.Dispose();
        t2d.Extents = extents;
        ShapeProperties sp = new ShapeProperties();
        sp.BlackWhiteMode = DocumentFormat.OpenXml.Drawing.BlackWhiteModeValues.Auto;
        sp.Transform2D = t2d;
        DocumentFormat.OpenXml.Drawing.PresetGeometry prstGeom = new DocumentFormat.OpenXml.Drawing.PresetGeometry();
        prstGeom.Preset = DocumentFormat.OpenXml.Drawing.ShapeTypeValues.Rectangle;
        prstGeom.AdjustValueList = new DocumentFormat.OpenXml.Drawing.AdjustValueList();
        sp.Append(prstGeom);
        sp.Append(new DocumentFormat.OpenXml.Drawing.NoFill());

        DocumentFormat.OpenXml.Drawing.Spreadsheet.Picture picture = new DocumentFormat.OpenXml.Drawing.Spreadsheet.Picture();
        picture.NonVisualPictureProperties = nvpp;
        picture.BlipFill = blipFill;
        picture.ShapeProperties = sp;

        Position pos = new Position();
        pos.X = x;
        pos.Y = y;
        Extent ext = new Extent();
        ext.Cx = extents.Cx;
        ext.Cy = extents.Cy;
        AbsoluteAnchor anchor = new AbsoluteAnchor();
        anchor.Position = pos;
        anchor.Extent = ext;
        anchor.Append(picture);
        anchor.Append(new ClientData());
        wsd.Append(anchor);
        wsd.Save(dp);
    }
    catch (Exception ex)
    {
        throw ex; // or do something more interesting if you want
    }
}

protected static void InsertImage(Worksheet ws, long x, long y, string sImagePath)
{
    InsertImage(ws, x, y, null, null, sImagePath);
}